*,*::before,*::after{box-sizing:border-box;margin:0;padding:0}
:root{
  --bg-primary:#0c0a09;
  --bg-secondary:#1c1917;
  --bg-card:#231f1b;
  --bg-card-hover:#2a2520;
  --text-primary:#faf5f0;
  --text-secondary:#bfb5a8;
  --text-muted:#8a7e72;
  --accent:#d4a056;
  --accent-dim:#a67b3d;
  --accent-glow:rgba(212,160,86,0.12);
  --accent-copper:#c87941;
  --accent-green:#6ec9a0;
  --border:#2e2824;
  --border-light:#3d3530;
  --warn:#e8a44a;
  --serif:'Playfair Display',Georgia,serif;
  --sans:'Outfit','Segoe UI',sans-serif;
  --mono:'JetBrains Mono','Courier New',monospace;
}
html{scroll-behavior:smooth;font-size:16px}
body{font-family:var(--sans);background:var(--bg-primary);color:var(--text-primary);line-height:1.7;overflow-x:hidden}
::selection{background:var(--accent);color:var(--bg-primary)}
::-webkit-scrollbar{width:8px}
::-webkit-scrollbar-track{background:var(--bg-primary)}
::-webkit-scrollbar-thumb{background:var(--border-light);border-radius:4px}
::-webkit-scrollbar-thumb:hover{background:var(--accent-dim)}

.container{max-width:1200px;margin:0 auto;padding:0 2rem}
.section-label{font-family:var(--mono);font-size:.72rem;letter-spacing:.22em;text-transform:uppercase;color:var(--accent);margin-bottom:1rem;display:flex;align-items:center;gap:.75rem}
.section-label::before{content:'';width:2.5rem;height:1px;background:linear-gradient(90deg,var(--accent),transparent)}
.section-title{font-family:var(--serif);font-size:clamp(2rem,4vw,3.2rem);line-height:1.15;margin-bottom:1.5rem;color:var(--text-primary)}
.section-title em{font-style:italic;color:var(--accent)}
.section-subtitle{font-size:1.1rem;color:var(--text-secondary);max-width:720px;line-height:1.85;font-weight:300}

/* ── NAV ── */
header{position:fixed;top:0;left:0;right:0;z-index:1000;transition:all .35s ease}
header.scrolled{background:rgba(12,10,9,0.93);backdrop-filter:blur(24px);border-bottom:1px solid var(--border)}
nav{display:flex;align-items:center;justify-content:space-between;padding:1.25rem 2rem;max-width:1200px;margin:0 auto}
.nav-brand{display:flex;align-items:center;gap:.7rem;text-decoration:none;color:var(--text-primary)}
.nav-brand-icon{width:36px;height:36px;border-radius:50%;background:linear-gradient(135deg,var(--accent),var(--accent-copper));display:flex;align-items:center;justify-content:center;font-family:var(--mono);font-weight:700;font-size:.7rem;color:var(--bg-primary)}
.nav-brand-text{font-family:var(--mono);font-size:.85rem;font-weight:500;letter-spacing:.04em}
.nav-brand-text span{color:var(--accent)}
.nav-links{display:flex;gap:2rem;align-items:center;list-style:none}
.nav-links a{text-decoration:none;color:var(--text-secondary);font-size:.85rem;font-weight:500;transition:color .2s;letter-spacing:.02em}
.nav-links a:hover{color:var(--accent)}
.nav-cta{background:linear-gradient(135deg,var(--accent),var(--accent-copper));color:var(--bg-primary);padding:.55rem 1.4rem;border-radius:100px;font-weight:600;font-size:.82rem;text-decoration:none;transition:all .25s}
.nav-cta:hover{transform:translateY(-1px);box-shadow:0 4px 20px rgba(212,160,86,0.3)}
.mobile-toggle{display:none;background:none;border:none;color:var(--text-primary);font-size:1.5rem;cursor:pointer}

/* ── PAGE HERO (sub-pages) ── */
.page-hero{padding:9rem 0 5rem;background:var(--bg-primary);position:relative;overflow:hidden}
.page-hero::before{content:'';position:absolute;top:-20%;right:-15%;width:600px;height:600px;background:radial-gradient(circle,rgba(212,160,86,0.06) 0%,transparent 65%);border-radius:50%}
.page-hero .container{position:relative;z-index:1}
.page-hero h1{font-family:var(--serif);font-size:clamp(2.4rem,5vw,3.8rem);line-height:1.1;margin-bottom:1.2rem}
.page-hero h1 em{font-style:italic;color:var(--accent)}
.page-hero-desc{font-size:1.1rem;color:var(--text-secondary);max-width:680px;line-height:1.85;font-weight:300;margin-bottom:2rem}
.breadcrumb{font-family:var(--mono);font-size:.72rem;color:var(--text-muted);margin-bottom:1.5rem;display:flex;align-items:center;gap:.5rem}
.breadcrumb a{color:var(--text-muted);text-decoration:none;transition:color .2s}
.breadcrumb a:hover{color:var(--accent)}
.breadcrumb span{color:var(--accent)}

/* ── HERO (homepage) ── */
.hero{min-height:100vh;display:flex;align-items:center;position:relative;overflow:hidden;padding:8rem 0 6rem}
.hero-bg{position:absolute;inset:0;z-index:0}
.hero-bg::before{content:'';position:absolute;top:-20%;right:-15%;width:700px;height:700px;background:radial-gradient(circle,rgba(212,160,86,0.06) 0%,transparent 65%);border-radius:50%}
.hero-bg::after{content:'';position:absolute;bottom:-25%;left:-10%;width:500px;height:500px;background:radial-gradient(circle,rgba(200,121,65,0.05) 0%,transparent 65%);border-radius:50%}
.hero-dots{position:absolute;inset:0;background-image:radial-gradient(circle,var(--border) 1px,transparent 1px);background-size:48px 48px;opacity:.2}
.hero .container{position:relative;z-index:1;display:grid;grid-template-columns:1.1fr .9fr;gap:4rem;align-items:center}
.hero-badge{display:inline-flex;align-items:center;gap:.5rem;background:var(--bg-card);border:1px solid var(--border-light);border-radius:100px;padding:.35rem 1rem .35rem .6rem;font-family:var(--mono);font-size:.72rem;color:var(--accent);margin-bottom:2rem}
.hero-badge-dot{width:6px;height:6px;border-radius:50%;background:var(--accent-green);animation:pulse 2s infinite}
@keyframes pulse{0%,100%{opacity:1}50%{opacity:.35}}
.hero h1{font-family:var(--serif);font-size:clamp(2.8rem,5.5vw,4.5rem);line-height:1.08;margin-bottom:1.5rem}
.hero h1 em{font-style:italic;color:var(--accent)}
.hero-desc{font-size:1.15rem;color:var(--text-secondary);line-height:1.85;max-width:560px;margin-bottom:2.5rem;font-weight:300}
.hero-actions{display:flex;gap:1rem;flex-wrap:wrap}
.btn-primary{background:linear-gradient(135deg,var(--accent),var(--accent-copper));color:var(--bg-primary);padding:.85rem 2rem;border-radius:100px;font-weight:600;font-size:.92rem;text-decoration:none;display:inline-flex;align-items:center;gap:.5rem;transition:all .25s;border:none;cursor:pointer}
.btn-primary:hover{transform:translateY(-2px);box-shadow:0 6px 30px rgba(212,160,86,0.25)}
.btn-secondary{background:transparent;color:var(--text-primary);padding:.85rem 2rem;border-radius:100px;font-weight:500;font-size:.92rem;text-decoration:none;display:inline-flex;align-items:center;gap:.5rem;transition:all .25s;border:1px solid var(--border-light)}
.btn-secondary:hover{border-color:var(--accent);color:var(--accent)}

.hero-visual{position:relative}
.molecule-card{background:var(--bg-card);border:1px solid var(--border-light);border-radius:20px;padding:2.5rem;position:relative;overflow:hidden}
.molecule-card::before{content:'';position:absolute;top:-1px;left:-1px;right:-1px;height:3px;background:linear-gradient(90deg,var(--accent),var(--accent-copper),transparent);border-radius:20px 20px 0 0}
.molecule-header{display:flex;justify-content:space-between;align-items:flex-start;margin-bottom:2rem}
.molecule-name{font-family:var(--serif);font-size:1.6rem;font-weight:600;color:var(--accent)}
.molecule-tag{background:rgba(212,160,86,0.1);border:1px solid var(--accent-dim);border-radius:100px;padding:.2rem .7rem;font-family:var(--mono);font-size:.68rem;color:var(--accent)}
.molecule-seq{font-family:var(--mono);font-size:.85rem;color:var(--text-muted);letter-spacing:.2em;margin-bottom:2rem;padding:1.25rem;background:var(--bg-primary);border-radius:12px;border:1px solid var(--border);text-align:center}
.molecule-stats{display:grid;grid-template-columns:1fr 1fr;gap:.75rem}
.mol-stat{padding:1rem;background:var(--bg-primary);border-radius:10px;border:1px solid var(--border)}
.mol-stat-label{font-family:var(--mono);font-size:.62rem;text-transform:uppercase;letter-spacing:.15em;color:var(--text-muted);margin-bottom:.3rem}
.mol-stat-value{font-size:1.05rem;font-weight:600;color:var(--text-primary)}

/* ── FACTS BAR ── */
.facts-bar{background:var(--bg-secondary);border-top:1px solid var(--border);border-bottom:1px solid var(--border);padding:3rem 0}
.facts-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:2rem}
.fact-item{text-align:center;padding:1rem}
.fact-number{font-family:var(--serif);font-size:2.5rem;color:var(--accent);margin-bottom:.2rem}
.fact-label{font-size:.82rem;color:var(--text-secondary);font-weight:400}

/* ── SECTIONS ── */
section{padding:6rem 0}
section:nth-child(even){background:var(--bg-secondary)}

/* ── MECHANISM CARDS ── */
.mechanism-grid{display:grid;grid-template-columns:1fr 1fr;gap:2rem;margin-top:3rem}
.mech-card{background:var(--bg-card);border:1px solid var(--border);border-radius:16px;padding:2rem;transition:all .3s ease;position:relative;overflow:hidden}
.mech-card:hover{border-color:var(--accent-dim);transform:translateY(-3px);box-shadow:0 12px 48px rgba(0,0,0,0.35)}
.mech-card::after{content:'';position:absolute;top:0;left:0;right:0;height:2px;background:linear-gradient(90deg,var(--accent),var(--accent-copper),transparent);opacity:0;transition:opacity .3s}
.mech-card:hover::after{opacity:1}
.mech-icon{width:48px;height:48px;border-radius:12px;background:var(--accent-glow);display:flex;align-items:center;justify-content:center;margin-bottom:1.25rem;font-size:1.25rem}
.mech-card h3{font-family:var(--serif);font-size:1.3rem;margin-bottom:.7rem}
.mech-card p{color:var(--text-secondary);font-size:.92rem;line-height:1.8}

/* ── RESEARCH TABLE ── */
.research-table-wrap{margin-top:3rem;overflow-x:auto;border-radius:16px;border:1px solid var(--border)}
table{width:100%;border-collapse:collapse;min-width:800px}
thead{background:var(--bg-card)}
th{padding:1rem 1.25rem;text-align:left;font-family:var(--mono);font-size:.72rem;text-transform:uppercase;letter-spacing:.12em;color:var(--accent);border-bottom:1px solid var(--border);font-weight:500}
td{padding:1rem 1.25rem;border-bottom:1px solid var(--border);font-size:.88rem;color:var(--text-secondary);vertical-align:top}
tr:hover td{background:var(--bg-card-hover)}
td a{color:var(--accent);text-decoration:none;font-family:var(--mono);font-size:.78rem}
td a:hover{text-decoration:underline}
.study-type{display:inline-block;padding:.15rem .5rem;border-radius:100px;font-family:var(--mono);font-size:.68rem;font-weight:500}
.type-invivo{background:rgba(212,160,86,0.1);color:var(--accent)}
.type-invitro{background:rgba(200,121,65,0.1);color:var(--accent-copper)}
.type-review{background:rgba(110,201,160,0.1);color:var(--accent-green)}
.type-clinical{background:rgba(212,160,86,0.15);color:#e8c570}

/* ── DOSING ── */
.dosing-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:2rem;margin-top:3rem}
.dose-card{background:var(--bg-card);border:1px solid var(--border);border-radius:16px;overflow:hidden;transition:all .3s}
.dose-card:hover{border-color:var(--accent-dim);box-shadow:0 8px 40px rgba(0,0,0,0.25)}
.dose-card-header{padding:1.5rem;border-bottom:1px solid var(--border);background:linear-gradient(135deg,var(--bg-card),var(--bg-card-hover))}
.dose-card-header h3{font-family:var(--serif);font-size:1.2rem;margin-bottom:.2rem}
.dose-card-header span{font-family:var(--mono);font-size:.72rem;color:var(--accent)}
.dose-card-body{padding:1.5rem}
.dose-row{display:flex;justify-content:space-between;padding:.55rem 0;border-bottom:1px solid var(--border);font-size:.88rem}
.dose-row:last-child{border:none}
.dose-row-label{color:var(--text-muted);font-weight:500}
.dose-row-value{color:var(--text-primary);font-family:var(--mono);font-size:.82rem}

/* ── SAFETY ── */
.safety-grid{display:grid;grid-template-columns:1fr 1fr;gap:3rem;margin-top:3rem}
.safety-block{background:var(--bg-card);border:1px solid var(--border);border-radius:16px;padding:2rem}
.safety-block h3{font-family:var(--serif);font-size:1.25rem;margin-bottom:1.2rem;display:flex;align-items:center;gap:.7rem}
.safety-list{list-style:none}
.safety-list li{padding:.55rem 0;color:var(--text-secondary);font-size:.92rem;display:flex;align-items:flex-start;gap:.7rem;border-bottom:1px solid var(--border)}
.safety-list li:last-child{border:none}
.safety-list li::before{content:'';width:5px;height:5px;border-radius:50%;background:var(--accent);margin-top:.6rem;flex-shrink:0}

/* ── CONTACT ── */
.contact-section{background:linear-gradient(180deg,var(--bg-primary),var(--bg-secondary))}
.contact-grid{display:grid;grid-template-columns:1fr 1fr;gap:4rem;margin-top:3rem;align-items:start}
.contact-info{background:var(--bg-card);border:1px solid var(--border-light);border-radius:20px;padding:2.5rem}
.contact-info h3{font-family:var(--serif);font-size:1.4rem;margin-bottom:1rem}
.contact-info>p{color:var(--text-secondary);margin-bottom:2rem;line-height:1.8;font-size:.95rem}
.contact-method{display:flex;align-items:center;gap:1rem;padding:1rem;background:var(--bg-primary);border:1px solid var(--border);border-radius:12px;margin-bottom:1rem;text-decoration:none;color:var(--text-primary);transition:all .2s}
.contact-method:hover{border-color:var(--accent);background:var(--accent-glow)}
.contact-method-icon{width:44px;height:44px;border-radius:12px;background:var(--accent-glow);display:flex;align-items:center;justify-content:center;font-size:1.15rem;flex-shrink:0}
.contact-method-text{font-size:.92rem;font-weight:500}
.contact-method-sub{font-size:.78rem;color:var(--text-muted);font-weight:400}
.qr-card{background:var(--bg-card);border:1px solid var(--border-light);border-radius:20px;padding:2.5rem;text-align:center}
.qr-card h3{font-family:var(--serif);font-size:1.4rem;margin-bottom:.5rem}
.qr-card>p{color:var(--text-secondary);margin-bottom:1.5rem;font-size:.92rem}
.qr-img{width:280px;height:280px;border-radius:16px;margin:0 auto;object-fit:contain}

/* ── DISCLAIMER ── */
.disclaimer{background:var(--bg-secondary);border-top:1px solid var(--border);padding:3rem 0}
.disclaimer-box{background:rgba(232,164,74,0.04);border:1px solid rgba(232,164,74,0.18);border-radius:16px;padding:2rem}
.disclaimer-box h3{color:var(--warn);font-family:var(--mono);font-size:.82rem;text-transform:uppercase;letter-spacing:.1em;margin-bottom:.7rem;display:flex;align-items:center;gap:.5rem}
.disclaimer-box p{color:var(--text-muted);font-size:.82rem;line-height:1.85}

/* ── REFERENCES ── */
.references{padding:4rem 0;background:var(--bg-primary)}
.ref-list{margin-top:2rem;columns:2;column-gap:2.5rem}
.ref-item{break-inside:avoid;margin-bottom:.85rem;padding:.7rem 1rem;background:var(--bg-card);border:1px solid var(--border);border-radius:10px;font-size:.78rem;color:var(--text-muted);line-height:1.7}
.ref-item strong{color:var(--text-secondary);font-weight:500}
.ref-item a{color:var(--accent);text-decoration:none}
.ref-item a:hover{text-decoration:underline}

/* ── FOOTER ── */
footer{background:var(--bg-primary);border-top:1px solid var(--border);padding:3rem 0}
.footer-inner{display:flex;justify-content:space-between;align-items:center}
.footer-brand{font-family:var(--mono);font-size:.82rem;color:var(--text-muted)}
.footer-brand span{color:var(--accent)}
.footer-links{display:flex;gap:1.5rem}
.footer-links a{color:var(--text-muted);font-size:.78rem;text-decoration:none;transition:color .2s}
.footer-links a:hover{color:var(--accent)}

/* ── PROSE ── */
.prose{max-width:800px}
.prose h3{font-family:var(--serif);font-size:1.35rem;margin:2.5rem 0 1rem}
.prose p{color:var(--text-secondary);font-size:.98rem;line-height:1.9;margin-bottom:1.2rem}
.prose strong{color:var(--text-primary);font-weight:600}
.prose sup{font-size:.68rem;color:var(--accent);font-family:var(--mono)}

/* ── RELATED PAGES ── */
.related-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:1.5rem;margin-top:2.5rem}
.related-card{background:var(--bg-card);border:1px solid var(--border);border-radius:14px;padding:1.5rem;text-decoration:none;color:var(--text-primary);transition:all .3s;display:block}
.related-card:hover{border-color:var(--accent-dim);transform:translateY(-2px);box-shadow:0 8px 32px rgba(0,0,0,0.3)}
.related-card-label{font-family:var(--mono);font-size:.65rem;letter-spacing:.15em;text-transform:uppercase;color:var(--accent);margin-bottom:.5rem}
.related-card h3{font-family:var(--serif);font-size:1.1rem;margin-bottom:.4rem}
.related-card p{font-size:.82rem;color:var(--text-secondary);line-height:1.6}

/* Ad slots */
.ad-container{margin:2rem auto;text-align:center;min-height:90px;max-width:728px}

/* ── RESPONSIVE ── */
@media(max-width:1024px){
  .hero .container{grid-template-columns:1fr}.hero-visual{display:none}
  .mechanism-grid,.safety-grid,.contact-grid{grid-template-columns:1fr}
  .dosing-grid{grid-template-columns:1fr}
  .ref-list{columns:1}
  .facts-grid{grid-template-columns:repeat(2,1fr)}
  .related-grid{grid-template-columns:1fr 1fr}
}
@media(max-width:768px){
  .nav-links{display:none}.mobile-toggle{display:block}
  nav{padding:1rem 1.5rem}.container{padding:0 1.5rem}
  section{padding:4rem 0}.facts-grid{grid-template-columns:1fr 1fr}
  .footer-inner{flex-direction:column;gap:1rem;text-align:center}
  .related-grid{grid-template-columns:1fr}
}

/* Fade-in */
.fade-in{opacity:0;transform:translateY(22px);transition:all .6s cubic-bezier(.22,1,.36,1)}
.fade-in.visible{opacity:1;transform:translateY(0)}